The North Dakota State Bison has another FBS opponent to play in the seasons to come. In the 2022 season, they will play at the University of Arizona Wildcats.

NDSU and Arizona will clash in Tuscon, AZ on Saturday, September 17, 2022. The Bison also have two other Pac-12 opponents on their schedules in upcoming seasons; road games at the Oregon Ducks in 2020, and the Colorado Buffaloes in 2024.

Teams in the Football Bowl Subdivision haven't had much success against the Bison, as NDSU holds a 9-3 record against them, including a 23-21 victory over the Iowa Hawkeyes. The Hawkeyes were ranked 11th in the nation at the time of their defeat.